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Selected Publications

Metformin-like Methylglyoxal Scavengers from Macroalgae Chondrus crispus and Gracilaria vermiculophyla Preserve Cell Viability.

George S. Hanna, Menny M. Benjamin, Latarsha Porcher, Sriram Vijayraghavan, Natalie Saini  and Mark T. Hamann

https://doi.org/10.3390/md24050169

Increased replication-associated single-stranded DNA promotes formaldehyde-induced mutagenesis.

Thomas Blouin, Charlotte McGuinness, Kierra Marshall, Caroline Bazzle,and Natalie Saini​

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BioRxiV (2026) doi: https://doi.org/10.64898/2026.04.24.720578

Translesion polymerases and DNA–protein crosslink repair shapes the cellular response to formaldehyde-induced DNA damage in ssDNA

Thomas Blouin, Elizabeth Ampolini, Kristina Stayer, Parameshwar Suresh, Piotr A Mieczkowski, Natalie Saini Nucleic Acids Research, Volume 53, Issue 17, 23 September 2025, gkaf914https://doi.org/10.1093/nar/gkaf914

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing

Sriram Vijayraghavan, Alessandra Ruggiero, Samuel Becker, Piotr A Mieczkowski, George S Hanna, Mark T Hamann, Natalie Saini, Nucleic Acids Research, 53(14) ,2025, gkaf705 https://doi.org/10.1093/nar/gkaf705

Multiple DNA repair pathways prevent acetaldehyde-induced mutagenesis in yeast 

Latarsha Porcher, Sriram Vijayraghavan, Yashvi Patel, Samuel Becker, Thomas Blouin, James McCollum, Piotr A Mieczkowski, Natalie Saini Genetics, iyae213, https://doi.org/10.1093/genetics/iyae213

Aldehyde-induced DNA-protein crosslinks- DNA damage, repair and mutagenesis

Thomas Blouin and Natalie Saini, Front. Oncol. 14:1478373. doi: 10.3389/fonc.2024.1478373

Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis

Sriram Vijayraghavan, Thomas Blouin, James McCollum, Latarsha Porcher, François Virard, Jiri Zavadil, Carol Feghali-Bostwick & Natalie Saini, Nature Communications volume 15, Article number: 8889 (2024) 

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See recent commentary in Scleroderma news here

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Also, check out the recent News and Views article on our work in Nature Reviews Rheumatology here

Aldehyde-Associated Mutagenesis─Current State of Knowledge
Sriram Vijayraghavan, Natalie Saini, Chem Res Toxicol​,  2023 Jun 26. doi:10.1021/acs.chemrestox.3c00045

Acetaldehyde makes a distinct mutation signature in single-stranded DNA
Sriram Vijayraghavan, Latarsha Porcher, Piotr A Mieczkowski, Natalie Saini.Nucleic Acids Research, gkac570, https://doi.org/10.1093/nar/gkac570

Publications from post-doc (NIEHS) and PhD (Georgia Tech)

Mutation signatures specific to DNA alkylating agents in yeast and cancers.

Saini N, Sterling JF, Sakofsky CJ, Giacobone CK, Klimczak LJ, Burkholder AB, Malc EP, Mieczkowski PA, Gordenin DA.Nucleic Acids Res. 2020 Apr 17;48(7):3692-3707. doi: 10.1093/nar/gkaa150.PMID: 32133535 

Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.
Sakofsky CJ, Saini N, Klimczak LJ, Chan K, Malc EP, Mieczkowski PA, Burkholder AB, Fargo D, Gordenin DA.PLoS Biol. 2019 Sep 30;17(9):e3000464. doi: 10.1371/journal.pbio.3000464. eCollection 2019 Sep.PMID: 31568516 

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature.

Degtyareva NP, Saini N, Sterling JF, Placentra VC, Klimczak LJ, Gordenin DA, Doetsch PW.PLoS Biol. 2019 May 8;17(5):e3000263. doi: 10.1371/journal.pbio.3000263. eCollection 2019 May.PMID: 31067233 

Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.

Saini N, Gordenin DA.Environ Mol Mutagen. 2018 Oct;59(8):672-686. doi: 10.1002/em.22215. Epub 2018 Aug 27.PMID: 30152078 

APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast.

Saini N, Roberts SA, Sterling JF, Malc EP, Mieczkowski PA, Gordenin DA.DNA Repair (Amst). 2017 May;53:4-14. doi: 10.1016/j.dnarep.2017.03.003. Epub 2017 Mar 21.PMID: 28351647 

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.

Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA, Gordenin DA.PLoS Genet. 2016 Oct 27;12(10):e1006385. doi: 10.1371/journal.pgen.1006385. eCollection 2016 Oct.PMID: 27788131

The journey of DNA repair.

Saini N.Trends Cancer. 2015 Dec 1;1(4):215-216. doi: 10.1016/j.trecan.2015.11.001.PMID: 26858989 

Migrating bubble during break-induced replication drives conservative DNA synthesis.

Saini N, Ramakrishnan S, Elango R, Ayyar S, Zhang Y, Deem A, Ira G, Haber JE, Lobachev KS, Malkova A.Nature. 2013 Oct 17;502(7471):389-92. doi: 10.1038/nature12584. Epub 2013 Sep 11.PMID: 24025772 

Fragile DNA motifs trigger mutagenesis at distant chromosomal loci in saccharomyces cerevisiae.

Saini N, Zhang Y, Nishida Y, Sheng Z, Choudhury S, Mieczkowski P, Lobachev KS.PLoS Genet. 2013 Jun;9(6):e1003551. doi: 10.1371/journal.pgen.1003551. Epub 2013 Jun 13.PMID: 23785298 

When secondary comes first--the importance of non-canonical DNA structures.

Saini N, Zhang Y, Usdin K, Lobachev KS.Biochimie. 2013 Feb;95(2):117-23. doi: 10.1016/j.biochi.2012.10.005. Epub 2012 Oct 16.PMID: 23084930 

Genome-wide screen reveals replication pathway for quasi-palindrome fragility dependent on homologous recombination.

Zhang Y, Saini N, Sheng Z, Lobachev KS.PLoS Genet. 2013;9(12):e1003979. doi: 10.1371/journal.pgen.1003979. Epub 2013 Dec 5.PMID: 24339793

The full list of my publications can be accessed here

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